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The causes of heat stroke usually result from working or exercising in a hot environment, indoors as well as outdoors. Warning signs are usually present that heat stroke is looming. It is crucial not to ignore these warning signs. Core body temperature may rise to a dangerously high level within only 10 to 15 minutes. Left untreated, heat stroke can quickly damage the brain, heart, kidneys and muscles. Immediate, active intervention is necessary to avoid coma and death.